Background. The aim of our study was to assess the subgingival profile of 9 periodontal pathogens, by means of real-time PCR,\nin a group of predialysis chronic kidney disease patients with and without periodontal disease and to identify the risk factors\nassociated with periodontal disease in these patients. Material and Methods. This is a single centre cross-sectional cohort study\nperformed on 70CKDpatients. Patients received a full-mouth periodontal examination and the following parameterswere assessed:\nperiodontal pocket depth (PPD), clinical attachment level, bleeding on probing, and plaque index; subgingival biofilm samples\nwere collected from the deepest periodontal pocket of each quadrant and were pooled in one transporting unit. Clinical data\nwere drawn from the medical file of the patients. Results. T. denticola (???? = 0.001), T. forsythia (P < 0.001), and P. micros (P =\n0.003) are significantly associated with periodontal disease in CKD subjects but in a multivariate model only age and T. forsythia\nremain independent risk factors for periodontal disease in patients with CKD. Conclusions. In our cohort, age and T. forsythia are\nindependently associated with periodontitis in CKD patients.Within the limits of this study, CKD was not significantly associated\nwith a particular subgingival periodontal pathogens profile in periodontitis patients.
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